Welcome and opening
Dr. Stanimir Hasurdjiev
Providing the right drug to the right patient at the right dose
Our Conference on Personalization, Pharmacogenetics and Pharmacogenomics is coming up and you are kindly invited to book the date in your calendar:
Sofia, Bulgaria (online event)
Recent studies demonstrate that individuals metabolize medications on a wide scale and have considerable variations in drug response and side effects based on their DNA.
Despite general sentiments, medical drugs do not have the same effect on separate people. It has been proven that medications are ineffective for a large percentage of patients with different conditions and diseases (cardiology, pulmonology, neurology, psychiatry, oncology, etc.). Why one and the same drug is really effective for one patient and not only unsuccessful, but also dangerous for another one? The answer is in the genes.
Pharmacogenetics and pharmacogenomics reflect the importance of individual‘s genetic information for optimization of treatment plan and disease management.
Pharmacogenetics is the field of study dealing with the variability of responses to medications due to variation in single genes. Pharmacogenetics takes into account a person’s genetic information regarding specific drug receptors and how drugs are transported and metabolized by the body. The goal of pharmacogenetics is to create an individualized drug therapy that allows for the best choice and dose of drugs.1
Pharmacogenomics is similar to pharmacogenetics, except that it typically involves the search for variations in multiple genes that are associated with variability in drug response. Since pharmacogenomics is one of the large-scale “omic” technologies, it can examine the entirety of the genome, rather than just single genes. Pharmacogenomic studies may also examine genetic variation among large groups of people (populations), for example, in order to see how different drugs might affect different racial or ethnic groups. 1
Pharmacogenetics and pharmacogenomics are often used interchangeably but do have distinct meanings. Although either term refers to the use of genetic information to guide therapeutic decision-making:
Pharmacogenetic/ Pharmacogenomic testing is available and used as an instrument to predict how an individual may process and metabolize hundreds of different medications including those used for treating cardio-vascular, pulmonary, neurological, psychiatric, oncological and many other disorders. This innovative approach enables medical treatment optimization and adverse reactions avoidance.
Organized by the Bulgarian Association for Personalized Medicine (BAPEMED) and the Biotech Atelier the Pharmacogenetics & Pharmacogenomics workshop will bring together leading local and international experts in the field to present interesting themes highlighting the potential of pharmacogenomic approach and to discuss benefits and barriers and how to move “from gaps to bridges”.
All times are in Eastern European Summer Time (EEST) / UTC +3
Dr. Stanimir Hasurdjiev
Prof. Dr. Victoria Sarafian
Prof. Ann Daly
Prof. Radka Kaneva
Prof. Joanne Hackett
Prof. Michael Oellerich, MD, HonMD, FAACC, FAMM, FFPath (RCPI), FRCPath
Prof. Dobrin Svinarov, MD
Assoc. Prof. Zdravka Medarova